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Either way Matt, the 50% probability of full expression of the sickle cell gene (esp. in a close proximity with others who have this gene expression) would take the “beneficial” out of the genepool within several generations, if left unchecked. Natural selection would then work the only thing it is capable of: performing as a conservative process. Benefit or no, the gene would eventually take itself out by either: 1.deteriorating through mutation,hence losing any beneficial aspect it may once have had 2.being bred right out of the gene pool, being replaced by the orig. healthy gene expression; 3. finding full expression (50% probability)and thus inducing sickle cell anemia, thus taking it out of the gene pool through death of the recipient. 3/25/2003 4:40:41 PM  

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